nginx 404 error please help me

Mon Aug 15 03:51:59 UTC 2011

my nginx web unusually show 404 not found why

the web error show

2011/08/12 03:43:28 [error] 23729#0: *1644359 connect() failed (110:
Connection timed out) while connecting to upstream, client:
***.***.***.*** , server: _*, request: "GET /iepngfix.htc HTTP/1.1",
upstream: "http://xxx.xxx.xxx.xxx:81/iepngfix.htc", host: "xxx.xxx.com"

Please Help me

Posted at Nginx Forum: http://forum.nginx.org/read.php?2,213791,213791#msg-213791