Open () failed (24 too many open files

[clubi64]

I have a lot of below error in error.log.
Open /home/user/... failed (24 too many open files.
So i search in google and config below files.
Limits.conf , sysctl.conf nginx.conf for adjust rlimit nofile.
I set open file limit to 999999 and fs.max to 2000000.

When i am geting error i used command ( lsof | wc -l )  for see total open
file that it show 16000.
 I use command ( cd /proc/nginx pid/limits ) it show max open file 999999.
 Now i am geting above error yet.
So what is problem?

Posted at Nginx Forum: https://forum.nginx.org/read.php?2,267827,267827#msg-267827